New articles


Resistance to drug treatment of acromegaly and ways to overcome it

Golounina O. O., Dzeranova L. K., Pigarova E. A., Belaya Zh. E.
Acromegaly is a severe disabling neuroendocrine disease caused by hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). The ...

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

Rymar O. D., Voevoda S. M., Shakhtshneider E. V., Stakhneva E. M., Mustafina S. V., Shcherbakova L. V.
Background: Hyperprolactinemia is one of the most common hypothalamic-pituitary-endocrine disorders in women of reproductive age, with the highest fre...

Polymorphic variants of ACE, AGT, AGTR1, MTHFR and NOS3 candidate genes connected with arterial hypertension as part of the metabolic syndrome among the shor people

Mulerova T. A., Tsygankova D. P., Ogarkov M. Yu.
Background: The problem of high blood pressure in the framework of metabolic syndrome (MS) is one of the most important for modern medicine in connect...

Efficacy of metformin for treatment and prevention of antipsychotic-induced overweight and obesity in women: an open-label, randomized, prospective placebo-controlled study

Yunilaynen O. A., Oleichik I. V., Sizov S. V., Baranov P. A., Starostina E. G.
Background: The prevalence of obesity and metabolic abnormalities is increased patients with mental disorders receiving psychopharmacotherapy, which s...

Association of the rs2167270 polymorphism of the leptin gene (LEP) with the intensity of pain in patients with osteoarthritis of the knee

Krylov M. Yu., Alekseeva L. I., Scharapova E. P.
Background: Osteoarthritis (OA) is a significant social problem as it is the most common disease of the joints. OA is a multifactorial disease in whic...

Risk Factors for Obesity Development in Different Periods of Childhood

Chubarov T. V., Bessonova A. V., Zhdanova O. A., Artyushchenko A. A., Sharshova O. G.
Obesity is an important health problem in many countries. Obesity among the child population is growing steadily, including the Russian Federation. De...

The importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatment

Tsvetkova E. S., Romantsova T. I., Poluektov M. G., Runova G. E., Glinkina I. V., Fadeev V. V.
Melatonin is a special hormone that act as an internal synchronizer of circadian rhythms, the organism physiology and behavior to the environmental da...

Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series

Kovaleva E. V., Eremkina A. K., Mokrysheva N. G.
Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and hyperphosphatemia, due to absent or inappropriately low serum parath...

Comparison of the effects of liraglutide and sibutramine in obese patients

Matveev G. A., Golikova T. I., Vasileva A. A., Vasilieva E. V., Babenko A. Y., Shlyakhto E. V.
Background: Obesity is a global noncommunicable pandemic. The low effectiveness of treating obesity is associated with the difficulty of maintaining w...

To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D

Suplotova L. A., Avdeeva V. A., Rozhinskaya L. Y.
The influence of obesity on human health, as a multifactorial and multigenic disorder, is a rather complex, interdisciplinary and at the same time ext...